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- W2350720932 abstract "Objective To explore the expression of proto-oncogene Wip1 in intracranial ependymomas and its relationship with P53.Methods Thirty-one intracranial ependymomas and 10 normal brain tissue samples were detected for Wip1 mRNA and protein expression by the uses of immunohistochemistry,RT-PCR and Western blot.Also,we detected P53 expression in 31 tumors through immunohistochemistry.Meanwhile,we reviewed patients' clinical data and its relationship with Wip1.Results The positive expression of Wip1 protein in ependymomas(19/31) was higher than that of normal brain tissues(1/10) significantly(P0.05).P53 positive staining was seen in 2 of 31 tumor tissues.The values of Wip1 mRNA in ependymomas were 0.34±0.07,which higher remarkably than normal brain tissues(0.05±0.01)(P0.05).The relative contents of Wip1 protein in ependymomas were 0.83±0.16,which higer remarkably than normal brain tissues(0.14±0.03)(P0.05).The expression of Wip1 had no relationship to tumor size,age and sex(P0.05).Conclusion The high expression of Wip1 in ependymomas may regulate negatively the expression of P53.Wip1 may play an important role in the tumor progress development and would be a new target for ependymomas therapy in the near future." @default.
- W2350720932 created "2016-06-24" @default.
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- W2350720932 date "2011-01-01" @default.
- W2350720932 modified "2023-09-25" @default.
- W2350720932 title "Over-expression of proto-oncogene Wip1 in intracranial ependymomas association with P53" @default.
- W2350720932 hasPublicationYear "2011" @default.
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