Matches in SemOpenAlex for { <https://semopenalex.org/work/W2350737897> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2350737897 abstract "Aim To detect the effect of neuropeptide Y (NPY) on the expression of low density lipoprotein receptors (LDLR) in human vascular smooth muscle cells (hVSMC). Methods The cultured hVSMC in vitro were divided into the control groups and the different concentration NPY groups (the concentrations of NPY were 10 8 mol/L, 10 7 mol/L, 10 6 mol/L and 10 5 mol/L). All groups were cultured for 6 h, 12 h, 24 h and 48 h respectively, then, were stained by the immunofluorescent histochemical staining and quantitatively assayed the effect of NPY on the expression of LDLR in hVSMC under laser scanning confocal microscope. Results The averaged fluorescent values of the LDLR expression in hVSMC of control groups were 2 428 to 2 527, and there were no significant differences among the different culture times (P0.05), while there were significant differences between the averaged fluorescent values in NPY groups and those in control groups (P0.05 or P0.01). The averaged fluorescent values were 1 798 to 2 408 in 10 8 mol/L NPY groups, 1 783 to 2 332 in 10 7 mol/L NPY groups, 1 722 to 2 281 in 10 6 mol/L NPY groups and 1 590 to 2 010 in 10 5 mol/L NPY groups during the different culture times, decreasing averagely by 15.59%, 19.78%, 21.91% and 26.83% compared with control groups respectively, and there were significant differences among most of the different concentration NPY groups (P0.01). NPY donwregulated the expression of LDLR in hVSMC with dose dependent and time dependent manner. Conclusion Neuropeptide Y could downregulate the expression of LDLR in hVSMC, then it probably resulted in blocking the LDLR mediated pathway, consequently LDL could accumulated in the vascular wall. This might be the important mechanism that neurofluid factor participated in the occurrence of atherosclerosis." @default.
- W2350737897 created "2016-06-24" @default.
- W2350737897 creator A5005296337 @default.
- W2350737897 date "2003-01-01" @default.
- W2350737897 modified "2023-09-25" @default.
- W2350737897 title "The Effect of the Neuropeptide Y on the Expression of Low Density Lipoprotein Receptor in Human Vascular Smooth Muscle Cells" @default.
- W2350737897 hasPublicationYear "2003" @default.
- W2350737897 type Work @default.
- W2350737897 sameAs 2350737897 @default.
- W2350737897 citedByCount "0" @default.
- W2350737897 crossrefType "journal-article" @default.
- W2350737897 hasAuthorship W2350737897A5005296337 @default.
- W2350737897 hasConcept C118303440 @default.
- W2350737897 hasConcept C124815738 @default.
- W2350737897 hasConcept C12554922 @default.
- W2350737897 hasConcept C126322002 @default.
- W2350737897 hasConcept C134018914 @default.
- W2350737897 hasConcept C170493617 @default.
- W2350737897 hasConcept C185592680 @default.
- W2350737897 hasConcept C202751555 @default.
- W2350737897 hasConcept C2778163477 @default.
- W2350737897 hasConcept C2779395532 @default.
- W2350737897 hasConcept C2780072125 @default.
- W2350737897 hasConcept C2992686903 @default.
- W2350737897 hasConcept C43554185 @default.
- W2350737897 hasConcept C54355233 @default.
- W2350737897 hasConcept C55493867 @default.
- W2350737897 hasConcept C71924100 @default.
- W2350737897 hasConcept C74864618 @default.
- W2350737897 hasConcept C86803240 @default.
- W2350737897 hasConcept C88412794 @default.
- W2350737897 hasConcept C93984277 @default.
- W2350737897 hasConceptScore W2350737897C118303440 @default.
- W2350737897 hasConceptScore W2350737897C124815738 @default.
- W2350737897 hasConceptScore W2350737897C12554922 @default.
- W2350737897 hasConceptScore W2350737897C126322002 @default.
- W2350737897 hasConceptScore W2350737897C134018914 @default.
- W2350737897 hasConceptScore W2350737897C170493617 @default.
- W2350737897 hasConceptScore W2350737897C185592680 @default.
- W2350737897 hasConceptScore W2350737897C202751555 @default.
- W2350737897 hasConceptScore W2350737897C2778163477 @default.
- W2350737897 hasConceptScore W2350737897C2779395532 @default.
- W2350737897 hasConceptScore W2350737897C2780072125 @default.
- W2350737897 hasConceptScore W2350737897C2992686903 @default.
- W2350737897 hasConceptScore W2350737897C43554185 @default.
- W2350737897 hasConceptScore W2350737897C54355233 @default.
- W2350737897 hasConceptScore W2350737897C55493867 @default.
- W2350737897 hasConceptScore W2350737897C71924100 @default.
- W2350737897 hasConceptScore W2350737897C74864618 @default.
- W2350737897 hasConceptScore W2350737897C86803240 @default.
- W2350737897 hasConceptScore W2350737897C88412794 @default.
- W2350737897 hasConceptScore W2350737897C93984277 @default.
- W2350737897 hasLocation W23507378971 @default.
- W2350737897 hasOpenAccess W2350737897 @default.
- W2350737897 hasPrimaryLocation W23507378971 @default.
- W2350737897 hasRelatedWork W2000791344 @default.
- W2350737897 hasRelatedWork W2023489639 @default.
- W2350737897 hasRelatedWork W2078727134 @default.
- W2350737897 hasRelatedWork W2342960040 @default.
- W2350737897 hasRelatedWork W2352436751 @default.
- W2350737897 hasRelatedWork W2356754082 @default.
- W2350737897 hasRelatedWork W2359526210 @default.
- W2350737897 hasRelatedWork W2378895577 @default.
- W2350737897 hasRelatedWork W2386286863 @default.
- W2350737897 hasRelatedWork W2393280643 @default.
- W2350737897 hasRelatedWork W2393821023 @default.
- W2350737897 hasRelatedWork W2394236852 @default.
- W2350737897 hasRelatedWork W2399658397 @default.
- W2350737897 hasRelatedWork W2410605027 @default.
- W2350737897 hasRelatedWork W2415262448 @default.
- W2350737897 hasRelatedWork W2424174183 @default.
- W2350737897 hasRelatedWork W3031233927 @default.
- W2350737897 hasRelatedWork W3031380107 @default.
- W2350737897 hasRelatedWork W3031751950 @default.
- W2350737897 hasRelatedWork W3031771092 @default.
- W2350737897 isParatext "false" @default.
- W2350737897 isRetracted "false" @default.
- W2350737897 magId "2350737897" @default.
- W2350737897 workType "article" @default.