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- W2350757894 abstract "Objective:To study the relationship between mutant p53 expression and apoptosis in hepatocellular carcinoma (HCC) from a high aflatoxin B1 contaminated area. Methods:Apoptotic cells and mutant p53 protein were detected by techniques of in situ terminal deoxynucleotide transferase labelling and immunohistochemical S P method in 56 paraffin embedded tissues of HCC. Results:Apoptotic index was 3 81‰in the HCC with positive expression of mutant p53, this was significant higher than that of 1 74‰in mutant p53 negative cases (P 0 05).Conclusions:The mutant p53 protein which is associated with aflatoxin B1 may stimulate malignant cell proliferation, meanwhile a higher apoptotic rate is the associated phenomenon of high proliferation rate, is contributory to selective proliferation of those clone with higher proliferative ability." @default.
- W2350757894 created "2016-06-24" @default.
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- W2350757894 date "1999-01-01" @default.
- W2350757894 modified "2023-09-25" @default.
- W2350757894 title "The relationship between apoptosis and mutant p53 associated with aflatoxin B1 in human hepatocellular carcinoma" @default.
- W2350757894 hasPublicationYear "1999" @default.
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