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- W2350774328 abstract "AIM To diagnose digestive tract cancer serologically using anti gallbladder mAb. METHODS Gallbladder associated antigen (GBAA) levels were measured by mAb for gallbladder cancer and conA in patients with digestive tract cancer, benign diseases and healthy controls. Serum CEA, AFP, CA19 9 and CA 242 levels were also measured simultaneously in the subjects. RESULTS The GBAA positive rates were as follows: 2 2% in normal controls, 13 3% in benign diseases, 92 3% in gallbladder cancer, 20 9% in hepatocelullar cancer, 9 1% in pancreas cancer, 50% in gastric cancer, 41 6% in colon cancer, 50% in bile duct cancer, 100% in cancer of the ampulla of Vater. In gallbladder cancer, hepatocelullar cancer, pancreas cancer, gastric cancer, colon cancer, bile duct cancer, ampulla of Vater cancer, CEA positive rates were 7 6%, 3 8%, 33 3%, 21 5%, 33 3%, 0% and 0% respectively, AFP positive rates 0%, 57%, 6%, 0%, 0% and 0%, respectively, CA19 9 positive rates 62%, 3 8%, 77 7%, 0%, 50%, 0% and 50%, respectively, and CA242 positive rates 62%, 0%, 66 6%, 0%, 50%, 0% and 25% respectively. The sensitivity and specificity in diagnosis of gallbladder cancer by GBAA were 92 3% and 94 1% respectively. The sensitivity in diagnosis of tumors of non gallbladder cancer was 32%. GBAA was also valuable for post operative or recurrence monitoring. No correlation was found between the GBAA and tumor sizes, infiltration, differentiation and metastasis. CONCLUSION Serum GBAA is useful for diagnosing gallbladder cancer, without cross reaction between GBAA and CEA or AFP." @default.
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- W2350774328 date "1997-01-01" @default.
- W2350774328 modified "2023-09-26" @default.
- W2350774328 title "Measurement of serum carcino associated antigen by anti gallbladder mAb in digestive tract cancer" @default.
- W2350774328 hasPublicationYear "1997" @default.
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