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- W2350782972 abstract "Objective: To study the changes of matrix metalloproteinase-9(MMP-9)/tissue inhibitors of metalloproteinase-1 (TIMP-1)and adiponectin in peripheral blood in patients with acute coronary syndrome (ACS) and explore the relationship between them. Methods: Patients with AMI(n=19), unstable angina (n=31),stable angina(n=13) and healthy control group (n=22) were included in this study. All the results were obtained by ABC-ELISA and analysed by independent t-test and correlation analysis. Results: In groups of AMI and UA, the levels of TIMP-1 and adiponectin in peripheral blood were significantly decreased compared with the healthy control group (P0.05-0.01),but MMP-9 level and MMP-9/TIMP-1 value were significantly increased (P 0.05-0.01). Adiponectin was obviously decreased (P0.05-0.01) and MMP-9/TIMP-1 was relatively increased (P0.01,p0.05)in AMI and UA groups compared with the SA group. Between the SA group and the healthy control group there were no obvious difference. The concentration of adiponectin was significantly positively correlated with TIMP-1(r=0.408, P0.01) and significantly negatively correlated with MMP-9/TIMP-1(r=0.478, P0.001). Conclusion: The decreased adiponectin affects the stabilization of plaque in coronary artery,and its relation with MMP-9/TIMP-1 may be an important factor in the occurence of ACS." @default.
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- W2350782972 date "2007-01-01" @default.
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- W2350782972 title "Relationship Between MMP-9/TIMP-1 and Adiponectin in Peripheral Blood in Patient With Acute Coronary Syndrome" @default.
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