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- W2350784982 abstract "AIM To verify the efficacy and safety of ziprasidone mesylate injection in the treatment of acute agitation of schizophrenia.METHODS Totally 86 hospitalized patients who met ICD- 10 criteria of schizophrenia were divided into ziprasidone group(n = 43) and haloperidol group(n = 43) in the single blind clinical trail.The ziprasidone group was given ziprasidone mesylate 10- 20 mg by intramuscular injection and the amount was less than 40 mg·d~(-1).The haloperidol group were given haloperidol 5- 10 mg by intramuscular injection and the amount was less than 30 mg·d~(-1).Drugs in the two groups could be repeated according to the state of illness 4- 6 h after the administration,and the daily injections were no more than 3 times and the course of treatment was 3 d.Before the treatment and 2,6,24,48,72 h after the treatment,the Positive and Negative Symptoms Scale(PANSS),Clinical Global Impression scale-the severity of the disease(CGI-SI),Adverse Reactions Scale(TESS) and the related lab tests were employed for assessing the efficacy and safety of the treatment.RESULTS Compared with the baseline,PANSS Excited Component(PANSS-EC) scores of the ziprasidone group decreased significantly at 2 h after the treatment.At other observation time-points,PANSS scores,PANSS-EC scores and CGI-SI scores in the two groups both decreased significandy(P 0.01) with no significant difference between the two groups(P 0.05).There were no significant difference between the total effective rates in the two groups(P 0.05).There were no serious adverse events in the two groups.The ziprasidone group had fewer extrapyramidal adverse reactions,and its incidence of adverse reactions(37%)were lower than that of the haloperidol group(53%)(x~2 = 2.30,P 0.05).CONCLUSION The mesylate ziprasidone injection is effective and safe in the treatment of acute agitation in schizophrenia with lower incidence of adverse reactions,and worth spreading clinically." @default.
- W2350784982 created "2016-06-24" @default.
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- W2350784982 date "2014-01-01" @default.
- W2350784982 modified "2023-09-25" @default.
- W2350784982 title "Clinical observation of ziprasidone mesylate injection in treatment of acute agitation of schizophrenia" @default.
- W2350784982 hasPublicationYear "2014" @default.
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