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- W2350804570 abstract "Objective To investigate the resistance to neuraminidase inhibitor( NAI) of influenza pandemic A( H1N1) 2009 viruses in Ningxia province,and to provide valuable information for antiviral therapeutics. Methods Totally 40 A( H1N1) pdm09 strains were selected from Ningxia influenza surveillance network during 2011- 2012,and all strains were performed neuraminidase( NA) genetic sequencing for analyzing the amino acid mutations related to NAI resistance,and 9 strains were performed chemiluminesce- based testing for detecting the sensibility of oseltamivir and zanamivir. Results The mutation sites of NA gene included M19 I,T60N /T,V106 I,V241I,N248 D,N369K,N386 S and D451 G among Ningxia A( H1N1) pdm09 strains,and no mutation sites related to resistance was found. Oseltamivir and zanamivir were sensitive to selected 9 strains. Conclusion Although oseltamivir and zanamivir are sensitive to influenza pandemic A( H1N1),2009 viruses in Ningxia province,we need to strengthen surveillance because of growing antiviral therapy patients and virus mutation." @default.
- W2350804570 created "2016-06-24" @default.
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- W2350804570 date "2015-01-01" @default.
- W2350804570 modified "2023-09-27" @default.
- W2350804570 title "Neuraminidase inhibitor resistance among influenza A(H1N1) viruses isolated from the mainland of Ningxia" @default.
- W2350804570 hasPublicationYear "2015" @default.
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