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- W2350804579 abstract "Objective: To observe the formation and structure of synapses between c hromaffin cells and cerebral cells of Parkinsonian SD rats treated with adrenal medulla allotransplants. Methods:Out of 40 wistar rats, for them unilateral nigro striatum was damaged by injecting 6-OHDA, 18 rats were qualified as Parkinsonian models and subjected subsequently to test. All rats were divided into two groups , experimenta l group(11 rats)and control group(7 rats). Adrenal medulla from healthy SD rats was transplanted into the striatum region of experimental group rats. The apomor phin-induced rotational behavior was tested and the formation and structure of s ynapses between transplanted chromaffin cells and host cerebral cells was observ ed by electron microscope. Results: The apomorphin-induced rotatio nal behavior w as significantly improved(P0.05)and the synapses were flourishingly formed betw een brain cells and chromaffin cells. 72.88% presynaptic membrance and 21.12% po st synaptic membranes of total synapses were from chromaffin cells. Concl usion: Following adrenal medulla transplantation, apomorphin-induced rotational behavio r was markedly improved and synapse connexion was formed and presynaptic membran e from chromaffin cells prevailed." @default.
- W2350804579 created "2016-06-24" @default.
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- W2350804579 date "2003-01-01" @default.
- W2350804579 modified "2023-09-26" @default.
- W2350804579 title "Observation on the Formation of Synapses Between Chromaffin Cells and Brain Cells of Parkinsonian Model Rats Allotransplanted With Adrenal Medulla" @default.
- W2350804579 hasPublicationYear "2003" @default.
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