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- W2350825771 abstract "OBJECTIVE To develop a high performance liquid chromatography-mass spectrometry(HPLC-MS/MS) method for simultaneous determination of E0703 and its metabolite E0703-tone and investigate pharmacokinetics of E0703 and E0703-tone in rhesus monkeys.METHODS After rhesus monkeys were po given E0703 10 mg·kg-1,blood samples were collected at different time points and pretreated by protein precipitation with acetonitrile.The supernatant diluted with deionized water was separated by HPLC on Capcell Pak C18 MG column.The mass spectrometer was operated in the positive ESI mode and detected by multiple reaction monitoring(MRM),E0703 and it′s metabolite E0703-tone were determined by HPLC-MS/MS.Pharmacokinetic parameters of E0703 and E0703-tone were calculated.RESULTS The linear range of E0703 and E0703-tone was both 0.625-500 μg·L-1.The intra-and inter-day precision was 7%.The intra-and inter-day accuracy was both within ±10%.Peak concentration(cmax) of E0703 and E0703-tone was 14.7 and 96.9 μg·L-1,respectively.Area under concentrations(AUC) of E0703 and E0703-tone was 173.0 and 1339.7 h·μg·L-1,and t1/2 was 6.6 and 11.8 h,respectively.CONCLUSION A sensitive and precise HPLC-MS/MS method is developed and validated.E0703 is metabolized to ketone metabolites(E0703-tone) in rhesus monkey.The pharmacokinetic behavior of E0703 is similar to that of E0703-tone according to concentration-time profiles.However,cmax and AUC of E0703-tone are much higher than those of E0703." @default.
- W2350825771 created "2016-06-24" @default.
- W2350825771 creator A5022315541 @default.
- W2350825771 date "2011-01-01" @default.
- W2350825771 modified "2023-09-24" @default.
- W2350825771 title "Pharmacokinetics of an effective radioprotector E0703 and its metabolite E0703-tone in rhesus monkeys" @default.
- W2350825771 hasPublicationYear "2011" @default.
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