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- W2350835998 abstract "Objective To observe the effect of sophoridine on endotoxin-induced acute liver injury in mice and its intervention action of the protein expression levels of phosphorylated ERK(pERK) in liver and the level of TNF-α in serum.Method It was recorded that general situation of mice with acute liver injury due to endotoxin,and the pathological changes in liver tissue were observed by light microscope.pERK expression and distribution was detected by immunohistochemical method,as well as TNF-α levels in serum were assayed by radioimmunity method.Results The general situation was improved and the liver pathological change was reduced in three-dose Sophoridine groups of mice.Compared with LPS group,LPS induced pERK translocation from cytoplasm to nuclear and the positive cells with pERK in liver tissue were significantly reduced(P0.01) and the level of TNF-α in serum significantly lower(P0.01) in middle and high-dose group,while compared with the normal control group,they were no significant difference(P0.05).Conclusion The present study shows a significant protective effect of Sophoridine on endotoxin-induced acute liver injury in mice and its mechanism is related to inhibition against the protein expression levels of pERK in liver and the level of TNF-α in serum." @default.
- W2350835998 created "2016-06-24" @default.
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- W2350835998 date "2010-01-01" @default.
- W2350835998 modified "2023-09-25" @default.
- W2350835998 title "Effect of sophoridine on endotoxin-induced acute liver injury in mice and its intervention action of the pERK and TNF-α expression" @default.
- W2350835998 hasPublicationYear "2010" @default.
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