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- W2350872385 abstract "Objective To investigate the pharmacokinetic interactions after oral administration of mosapride citrate,omeprazole and hydrochloride fluoxetine in treatment of rats with functional dyspesia.Methods Four groups of male SD rats(Ⅰ,Ⅱ,Ⅲ,Ⅳ,n=6 per group) were set in parallel design,the rats were given mosapride citrate,omeprazole,fluoxetine and combination of the three single doses,by intragastric administration.The determination of plasma samples were performed by a HPLC-MS/MS and the pharmacokinetic parameters were estimated(DAS 2.0).Results The Cmax and AUC of mosapride citrate,as well as omeprazole,were significantly increased;the AUC of hydrochlorid fluoxetine were increased,and CL/F of mosapride citrate,omeprazole and hydrochloride fluoxetine was decreased.Conclusion The results of preliminary study showed that there were obvious pharmacokinetic interactions among mosapride citrate,omeprazole and hydrochloride fluoxetine.The dosage of the three drugs was suggested to be reduced appropriately in their combination therapy." @default.
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- W2350872385 date "2012-01-01" @default.
- W2350872385 modified "2023-09-23" @default.
- W2350872385 title "Study on the Pharmacokinetics of Combined Medication in Treatment of Rats with Functional Dyspepsia" @default.
- W2350872385 hasPublicationYear "2012" @default.
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