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- W2350872473 abstract "[Objective] To investigate the signaling pathway involved in the inhibition of apoptotic effect during myocardium ischemia reperfusion with Qidan Tongmai tablet. [Methods] Male SD rats were divided randomly into four groups. Male Sprague-Dawley rats were anesthetized and open-chest animals were subject to 40 min of mycardial ischemia followed by 4h-reperfusion. Cardiac myocyte apoptosis was determined both qualitatively and quantitatively by terminal deoxynucleotidyl transfease-mediated dUTP nick-end labeling (TUNEL) methods. The state of PI3K signaling cascade was determined by Westernbloting analysis. [Result] Apoptosis index (AI) was attenuated from (20.3±4.5)% in control vs (11.6±2.3)% in QDTMT-treated animals. The state of p-Akt was induced a 2.5 fold increase by QDTMT administration. LY294002 abrogated the anti apoptosis effect. [(17.0±5.5)% vs (20.3±4.5)%]. [Conclusion] the results suggest that QDTMT may be able to inhibit the myocyte apoptosis against reperfusion-induced injury mediated by the increase of phosphorylating Akt." @default.
- W2350872473 created "2016-06-24" @default.
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- W2350872473 date "2007-01-01" @default.
- W2350872473 modified "2023-09-24" @default.
- W2350872473 title "Anti apoptotic effect of Qidan Tongmai tablet in myocardium ischemia-reperfusion injury mediated by PI3K/Akt signaling pathway" @default.
- W2350872473 hasPublicationYear "2007" @default.
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