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- W2350873119 abstract "Objective To study the regulation of TBK1,which plays a significant role in host anti-virus infection and was employed as bait protein for screening its binding protein by yeast two-hybrid assay.From among proteins that might interact with TBK1,estrogen receptor related receptor α(ERRα) was selected.In this study,we further investigated the interaction of these two proteins and the regulation of TBK1 by ERRα.Methods Firstly,the interaction between ERRα and TBK1 was demonstrated by co-immunoprecipitation.Secondly,the regulation of TBK1-mediated pathway by ERRα was analyzed by IFN-β luciferase reporter assays.To find out more about the impact of ERRα on IFN-β-induced signaling pathway,stable cell lines of ERRα knockdown were constructed using interference RNA(RNAi).Results ERRα coucd bind to TBK1 in 293 cells both in vivo and in vitro.ERRα downregulated the expression of IFN-β caused by VSV virus,polyI:C and TBK1.The expression of IFN-β was enhanced after ERRα was knocked down.Conclusion ERRα and TBK1 can interact in 293 cells.ERRα inhibits TBK1-mediated activation of IFN-β." @default.
- W2350873119 created "2016-06-24" @default.
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- W2350873119 date "2011-01-01" @default.
- W2350873119 modified "2023-09-24" @default.
- W2350873119 title "Regulation of TBK1-mediated pathway by ERRα" @default.
- W2350873119 hasPublicationYear "2011" @default.
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