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- W2350874027 abstract "Objective To study the effects of CD4~+ T lymphocytes on processing mononuclear phagocyte in patients with asthma. Methods The mononuclear phagocytes and CD4~+ T lymphocytes were isolated from peripheral blood in 20 patients with asthma and 22 healthy donors, respectively. Every sample was divided into four groups:MΦA~+,(MΦCD4~+)A~+,MΦ~+CD4~+A~+,and MΦA~+CD4~+. All groups were stimulated with CTLL 2P antigen for 18 hours and CTLL 2P antigen were washed away, then they were cultured with B lymphocytes together, the levels of secreted CTLL 2P-specific IgM, IgG, and IgE in the supernatant were measured after 10 days. Results When CD4~+ T lymphocytes were cultured with mononuclear phagocytes together, the level of CTLL 2 P-specific IgM of patients with asthma (A 490 nm)(0.033±0.031) was lower than that of healthy donors(0.098±0.062)(P0.05); the level of CTLL 2 P-specific IgG of patients with asthma (A 490 nm)(0.080±0.035)was significantly higher than that of healthy donors(0.055±0.024)(P0.05);the same result was obstained (P0.05), when primate CD4~+ T lymphocytes were cultured with antigen processing mononuclear phagocytes (patients:0.075±0.018,healthy donors:0.057±0.018). The CTLL 2 P-specific IgE level of patients with asthma(0.154±0.119) was as same as healthy donors (0.186±0.101)(P0.05). Conclusion The CD4~+ T lymphocytes of patients with asthma have different regulatory functions on immunolglobulins from antigen processing mononuclear phagocytes." @default.
- W2350874027 created "2016-06-24" @default.
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- W2350874027 date "2005-01-01" @default.
- W2350874027 modified "2023-09-22" @default.
- W2350874027 title "Effects of CD4~+T lymphocytes on processing mononuclear phagocyte in patients with asthma" @default.
- W2350874027 hasPublicationYear "2005" @default.
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