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- W2350876958 abstract "Objective To investigate the effects of gene transfer of recombinant adenovirus mediated brain derived neurotrophic factor(BDNF) on neurons after nerve root injury. Methods Based on the nerve root suture, the vector of recombinant adenovirus mediated brain derived neurotrophic factor was transferred into spinal anterior horn through non invasive injection. Activities of acetylcholinesterase and acid phosphatase were measured by chromatometry at days 1, 3, 7, 14 and 28 after operation. Results The activity of acetylcholinesterase in AxCA BDNF group was higher but that of acid phosphatase was lower than that in injury group. AxCA BDNF lowered the change range of enzyme. Conclusion Nerve root reconstruction combined with BDNF gene therapy can obviously relieve the injury of neurons, which is a new and effective method for the treatment of nerve root injury." @default.
- W2350876958 created "2016-06-24" @default.
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- W2350876958 date "2003-01-01" @default.
- W2350876958 modified "2023-09-25" @default.
- W2350876958 title "Effects of gene transfer of adenovirus-mediated BDNF into spinal cord on enzyme of neurons after nerve root injury" @default.
- W2350876958 hasPublicationYear "2003" @default.
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