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- W2350877033 abstract "Objective To investigate the effects of Na2SeO3 combined with Vitamin C on the activities of SOD,GSH-PX,the content of MDA in the liver and kidney of mice,and mitotic division of vaginal epithelium.Methods Female Kunming mice were used to establish the mitotic division model of vaginal epitheliums.They were randomly divided into eight groups:the negative control,the positive control,the low,middle and high dosage of Na2SeO3,and the low,middle and high dosage of Na2SeO3 and Vitamin C.The corresponding reagent was administered for twelve consecutive days.One hour after the last administration,colchicines were injected into the abdomen of the mice,and then the mice were sacrificed by removing the cervical vertebrae.Kidney and liver tissues were made homogenate for determining the enzymatic activity.Simultaneously,vaginal mitotic division was observed under a light microscope.Results Activities of SOD and GSH-PX in livers and activities of GSH-PX in kidneys in each selenium replenished group and methotrexate group were significantly higher than in the negative control group(P0.05),while the MDA content difference was not statistical significant among them.Both Na2SeO3 and Na2SeO3-Vitamin C could obviously inhibit mitoses of vaginal epithelial cells(P0.05),but no statistically significance was found between them and the positive control group.Conclusion Na2SeO3 could raise activities of GSH-PX in livers and kidneys,promote the effect of anti-oxidizing system and thus effectively inhibits the mitotic division of vaginal epithelium.Na2SeO3 and Vitamin C may not act in coordination." @default.
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- W2350877033 date "2007-01-01" @default.
- W2350877033 modified "2023-09-26" @default.
- W2350877033 title "Combination of Selenium and Vitamin C inhibits Psoriasis" @default.
- W2350877033 hasPublicationYear "2007" @default.
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