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• W2350877213 abstract "Objective To investigate the effects of intracortical transplantation of genetically modified myoblasts producing brain derived neurotrophic factor on locomotion and neurobehavior in neonatal rats subjected to hypoxic ischemic encephalopathy (HIE). Methods Fifty eight 7 day old pups were randomized into shamoperated group (C, 11 pups), HIE Plus BDNF transplantation group (B, 21 pups) and HIE Plus mock transplantation group (A, 26 pups). A rat myoblast cell line expressing BDNF (BDNF(+)/L 6TG) was constructed with the identification of BDNF mRNA expression and BDNF bioactivity by Northern blotting and bioassay with PC12 cells. A unilateral stereoaxical tranplantation of either BDNF (+)/L 6TG(B) or BDNF( ) /L 6TG(absence of BDNF, A) at 0.8 μl of cell suspension (4×10 4/μl ) into the left cortex of the brain was carried out shortly after HIE undergone by ligation of left common carotid artery in animals in group B or A, followed by a 2.5 h inhalation of humidified 8% O 2 Plus 92% N 2 at 37℃. Locomotive and neurobehavioral changes were observed during 29～ 42 d after the graft using both declinational critical angle test and open field test. The group C served as basal control. Results That the genetically modified myoblasts expressed and released BDNF in vitro was confirmed by Northern blotting and culture supernatant promoting the survival of PC12 cells and outgrowth of their dendrites. Mortality of the injured pups in 42 d after HIE was significantly reduced in group B (6/21) vs group A (15/26) ( P 0.05). Declinational critical angles were markedly increased in group B compared to group A at all the time points observed, although they were still smaller than those in group C. Similar change patterns were seen in open field test. Conclusion The present data suggest that genetically modified myoblasts expressing and secreting bioactive BDNF in vitro exert a protective function of reducing locomotive and neurbehavioral abnormalities as well as the mortality rate of HIE rats after being transplanted into HIE brain." @default.
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• W2350877213 date "2002-01-01" @default.
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• W2350877213 title "Effects of unilateral cortex transplantation of genetically modified myoblasts on locomotion and neurobeha- vior of neonatal rats subjected to hypoxic-ischemic encephalopathy" @default.
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