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- W2350894612 abstract "Objective:To explore the possible relationship of gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) expression with human epithelial ovarian carcinoma cell proliferation and differentiation. Methods: Proliferating cells nuclear antigen(PCNA),GnRH and its receptor were detected in 49 human epithelial ovarian carcinoma (HOC) and 15 ovarian benigh tumour by immunohistochemical SABC technique. Results:GnRH and its receptor had the same distribution pattern in HOC cells. The positive region was found mainly on the surface and in the cytoplasm of HOC cells. The PCNA labeling index was(26.1±15.2)% in GnRH positive HOCs, and (45.2±28.7)% in GnRH negative HOC respectively, the difference was significant(P0.05). Similarly, GnRHR positive HOC also had a lower PCNA labeling inde(21.1±14.2)% than that of GnRHR negative HOC(38.6士29.1)% (P0.01).Conclusion:GnRH might be involved in the regulation of human HOC cell proliferation and differentiation." @default.
- W2350894612 created "2016-06-24" @default.
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- W2350894612 date "2006-01-01" @default.
- W2350894612 modified "2023-09-25" @default.
- W2350894612 title "Relations of gonadotropin releasing hormone and its receptor expression with human epithelial ovarian carcinoma cells proliferation and differentiation" @default.
- W2350894612 hasPublicationYear "2006" @default.
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