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- W2350905087 abstract "AIM: To observe the expression of cell cycle regulating genes p16, p21 and CyclinD 1 in autologous vein graft (AVG) and its relation with proliferation of smooth muscle cell (SMC). METHODS: A model of proliferation of SMC in AVG was established in New Zealand rabbits. Proliferating cell nuclear antigen (PCNA) on different time spots post vein graft implantation was detected with immunohistochemistry and the expression of p16, p21 and CyclinD 1 mRNA in neointima of AVG was observed. Their correlation with the proliferation of SMC was analyzed. RESULTS: No expression of p16 mRNA was observed in the normal veins. Lower level expression was seen 1～2 wk postoperation and there was no correlation between the expression level of p16 mRNA and the proliferation of SMC. Lower level expression of p21 mRNA was detected in the normal veins. The expression increased 4～8 wk post implantation and decreased significantly in 12 wk. The expression level of p21 mRNA in intima (1～8 wk) was correlated negatively with the proliferation of SMC. Lower level expression of CyclinD 1 was observed in the normal veins. The peak level of expression occurred in 1～2 weeks post implantation. The trend of this expression was correlated positively with the proliferation of SMC. CONCLUSION: The results suggest that p16 has no regulatory effects on the proliferation of SMC of vein grafts. p21 inhibits the proliferation, while CyclinD 1 stimulates this process." @default.
- W2350905087 created "2016-06-24" @default.
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- W2350905087 date "2003-01-01" @default.
- W2350905087 modified "2023-09-28" @default.
- W2350905087 title "Relationship between the expression of p16, p21 and CyclinD_1 mRNA and the proliferation of SMC in autologous vein graft" @default.
- W2350905087 hasPublicationYear "2003" @default.
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