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- W2350929623 abstract "Objective To discuss the clinical value of cystatin C in the early diagnosis of contrast-induced nephropathy(CIN) after coronary angiography(CAG) and/or percutaneous coronary intervention(PCI).Methods A total of 200 patients underwent CAG and / or PCI were enrolled in this study.The levels of serum creatinine(Scr) were tested on 24 hours and 48 hours before and after the operations.The urine of patients was collected before the operation and 2 h,6 h,12 h,24 h,48 h after the operation to test the level of Cystatin C.Receiver operating characteristic(ROC) analyses were conducted to evaluate their value in the early diagnosis of CIN.Results There were 23 cases of CIN.The level of Cystatin C at 12 h,24 h and 48 h after the operation were 196.83 ± 43.05 ng / ml,302.15 ± 70.60 ng / ml and 130.84 ± 30.99 ng / ml,respectively,and were higher than that(47.45 ±17.02 ng/ml) before the operations.The difference was significant(P 0.05).There was no significant difference in Scr level before and after the operation(24 h),revealed that CIN can be diagnosed by urine Cystatin C at least 24 h ahead of Scr.AUC(95% CI) was 0.608 to 0.828.If the cutoff value of the diagnosis of CIN by the urine Cystatin C was 181.71ng / ml,the sensitivity should be 82.6% and the specificity should be 62.0%.Bivariate shows that the level of Cystatin C before and 24 h,48 h after the operation was positively correlated with Scr levels at the same time points.Conclusion Urinary Cystatin C may be a good biomarker for the early diagnosis of CIN after coronary angiography(CAG) and / or percutaneous coronary intervention(PCI)." @default.
- W2350929623 created "2016-06-24" @default.
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- W2350929623 date "2013-01-01" @default.
- W2350929623 modified "2023-09-24" @default.
- W2350929623 title "Value of Cystatin C in Early Diagnosis of Contrast-induced Nephropathy after Coronary Angiography and Intervention" @default.
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