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- W2350951505 abstract "To evaluate the safety and immunogenicity of a combined hepatitis A and hepatitis B-Bilive TM vaccine in healthy adult volunteers in Guangxi province and Hebei province of China,adult volunteers were selected from 16 year-old to 20 year-old students of a senior high school.Those who were susceptible to both HAV and HBV,HAV only and HBV only were assigned to group AB,A and B,respectively,who were then vaccinated with three doses(0,1 and 6 month schedule)of combined hepatitis A and B vaccine,respectively.The dosage was 500U for hepatitis A antigen and 10μg for hepatitis B surface antigen.The potential adverse effects were observed within 72 hours after vaccination.The serum samples were collected for the testing of anti-HAV and anti-HBs at month 2 and 7 after initial dose.The local and systemic adverse reactions after the primary immunization and the booster immunization were slight and temporary in AB group;the systemic adverse effect was low fever.Both of local and systemic adverse effects were disappeared without treatment within 72 hours.The sero-conversion rate of HAV in AB and A group was 100% one month after 3 doses;the GMT was 22 663 mIU/ml and 23 311mIU/ml respectively.The sero-conversion rate of HBV in AB and B group was 97.71% and 96.89% one month after 3 doses;the GMT was 107mIU/ml and 97mIU/ml respectively.There was no statistically significant difference on sero-conversion rate and GMT among combined group and control groups.Therefore,it has the same safety and immunogemicity to apply the combined hepatitis A and B vaccine to volunteers as compared to mono- valent inativated HA vaccine and recombinant yeast-derived monovalent HB vaccine." @default.
- W2350951505 created "2016-06-24" @default.
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- W2350951505 date "2004-01-01" @default.
- W2350951505 modified "2023-09-24" @default.
- W2350951505 title "Safety and Immunogenicity of a Combined Hepatitis A and Hepatitis B-Bilive~(TM) Vaccine in Healthy Adult Volunteers" @default.
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