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- W2350956869 abstract "To study the damage effects of individual and combined exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)and polychlorinated biphenyls (PCBs) on DNA in peripheral blood lymphocyte of rats, twenty Sprague-Dawley male rats were randomly and equally divided into 4 groups, and were treated intragastrically with vehicle (olive oil), Aroclor 1254(Aroclor 1254 10mg·kg-1), TCDD(TCDD 10μg·kg-1)and the combination(TCDD 10μg·kg-1+Aroclor 1254 10mg·kg-1)once a day for 6 consecutive days, respectively. The clinical signs and the body weight were recorded during the treatment. After 6-d exposure, peripheral blood lymphocytes were obtained and detected for DNA damage by single cell gel electrophoresis (SCGE). Tail Length, Tail DNA % and Tail Moment were analyzed by SCGE image analysis software (CASP). Results showed that the body weight of rats decreased significantly in the TCDD group and the combined group after treatment, and this effect was greater in the combined group. Significant DNA damage was observed in both TCDD group and the combined group, as evidenced by significantly higher Tail Length, Tail DNA % and Tail Moment than those in the control (p0.05), and the DNA damage was more severe in the combined group. However, no obvious DNA damage was observed in Aroclor 1254 group. Factorial analyse of the results showed that the effect of combination of TCDD with Aroclor 1254 on peripheral blood lymphocytes of rats may be synergic. The present study demonstrated that the combined exposure to TCDD and Aroclor 1254 aggravates DNA damage in peripheral blood lymphocyte of rats, indicating that it is important to understand the combined toxic effects in the risk assessment of coexposure of PCBs and TCDD." @default.
- W2350956869 created "2016-06-24" @default.
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- W2350956869 date "2009-01-01" @default.
- W2350956869 modified "2023-09-23" @default.
- W2350956869 title "Damage Effects of Individual and Combined Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Aroclor 1254 on DNA in Peripheral Blood Lymphocyte of Rats" @default.
- W2350956869 hasPublicationYear "2009" @default.
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