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- W2350996966 abstract "To observe the antiarrhythmic effects of matrine(MT). Arrhythmic model was maked by in jection iv of aconitine ,or barium chloride or calcium choride-acetylcholine mixture in rats. MT 15×10 -6 and 30×10 -6 could it markedly inhib markedly the ventricular arrhythmias induced by aconitine 20×10 -9 or BCL 2×10 -6 or coronary ligation in rat. It also obviously reduced the incidence of atrium fibrillation produced by CCL-Ach (CaCl 20.6%+Ach 0.0 025%) 10 ml/kg in mice. These actions were similar to Quinidine. The ECG of rats was significantly P-R chan-ged after i.v of MT 15×10 -6 . MT slows the heart rate and prolongs the P-R and Q-T intervals. [Conclusion] Matrine has obvious ontiarrhythmic effect in rats." @default.
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- W2350996966 date "2002-01-01" @default.
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- W2350996966 title "Experimental studies of antiarrhythmic effects of matrine" @default.
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