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- W2350998154 abstract "Objective To investigate the inhibition of ferulic acid(FA) on vascular smooth muscle cells(VSMCs) proliferation.Method Human umbilical VSMCs were obtained from umbilical artery by the attached explant method.The cell cytotoxicity of FA was measured by trypan blue exclusion test,and the effect of FA on serum-induced proliferation of VSMCs was evaluated by MTT assay.The variance of total protein was determined by Bradford method,and DNA synthesis was investigated by human BrdU ELISA.Result FA reversibly delayed the logarithm growth times of VSMC.At concentration of 100 μmol/L,FA inhibited cell proliferation by 61.32% without significant cytotoxicity.Moreover,FA inhibited the cell protein and DNA synthesis in dose-dependent manner.Conclusion Ferulic acid might contribute to the prevention and treatment of atherosclerosis through inhibiting SMC proliferation." @default.
- W2350998154 created "2016-06-24" @default.
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- W2350998154 date "2010-01-01" @default.
- W2350998154 modified "2023-09-23" @default.
- W2350998154 title "INHIBITION OF FERULIC ACID ON VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION" @default.
- W2350998154 hasPublicationYear "2010" @default.
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