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- W2351001675 abstract "Objective:To study the variation feature and clinical significance of T cell subsets of peripheral blood in AS and RA patients.Methods: The ratios of CD_4~+/CD_8~+ in peripheral blood,percentages of CD_4~+and CD_8~+ T cells were analyzed by immunofluorescence staining and bicolor flow cytometry(FCM) in vitro.Results: The ratio of CD_4~+T/CD_8~+T cells in AS cases was obviously lower than healthy control(1.73±0.33).FCM showed that the average percentages of CD_4~+ and CD_8~+ in AS was 32.72%±3.72% and 27.40%±5.03% versus 40.15%±4.63% and 23.73%±4.10% in healthy control.The average percentage of CD_4~+ decreased while CD_8~+ increased obviously(P0.05).The average percentages of CD_4~+(33.53%±3.70%)and CD_8~+(15.48%±2.38%) in RA versus healthy control were decreased significantly,while the ratios of CD_4~+T/CD_8~+T(2.43±0.13) increased obviously(P0.05).The average percentage of CD_8~+ in AS cases was much higher than that in RA cases( P0.05),the ratios of CD_4~+T/ CD_8~+T in AS patients was very lower than that in RA cases(P0.05).Conclusion:The findings suggest that immune hypofunction in AS patients may be relevant to its immunopathogenesis,and Immune hyperfunction in RA may also be concerned with its immunopathogenic difference.Therefore the feature of the ratios of CD_4~+T/CD_8~+T can be helpful for clinical differential diagnosis as well as cases observation." @default.
- W2351001675 created "2016-06-24" @default.
- W2351001675 creator A5065697046 @default.
- W2351001675 date "2006-01-01" @default.
- W2351001675 modified "2023-09-25" @default.
- W2351001675 title "Clinical Significance and Expression of T Cell Subsets of Peripheral Blood in AS and RA Patients" @default.
- W2351001675 hasPublicationYear "2006" @default.
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