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- W2351004097 abstract "The W-3Bao mouse, which was obtained in previous ENU mutagenesisproject, is a new mutant caused by the nonsense mutation of Kit gene.Mating and gross observing combining with PCR and sequencing were usedfor determining the genotypes of the W-3Bao mice. Embryonicdevelopment, hematological detection and histopathologic sectionmethods were used for their phenotype analysis. The results showed thatthe W-3Bao/+ mouse was white belly, white limb terminals and white tailtip. However, there was no difference of the external appearance amongthe W-3Bao/+, W-3Bao/3Bao and wild type mice for the embryo of 12.5days. The W-3Bao/3Bao embryos looked pale since pregnant 14.5 days anddwarf since pregnant 16.5 days. The extremely low level ofhaematochrome and big red blood cells of W-3Bao/3Bao 18.5-day-embryoswere found in the inspections of blood routine items and blood smear,which resulted in death of W-3Bao/3Bao homozygous mouse around beingborn, and no live postnatal W-3Bao/3Bao mouse was found in this study.No spermatogonium at different developmental stages was found in somecontorted seminiferous tubules in adult W-3Bao/+ mouse. At the age of18.5-day embryo, the spermatogonium of W-3Bao/3Bao mice only lied ininterstitial tissue and no one lied in contorted seminiferous tubules,while the spermatogonium of W-3Bao/+ or W+/+ mice lied in interstitialtissue and in contorted seminiferous tubules in the same time. At theage of 18.5-day embryo, cells arranged irregularly and primordialfollicles were not seen in the W-3Bao/3Bao ovaries, while primordialfollicles appeared clearly in the ovaries of W-3Bao/+ or W+/+ mice. Weconcluded that because of the nonsense mutation of Kit gene, theW-3Bao/+ mice show white spot and abnormal development of somecontorted seminiferous tubules. The W-3Bao/3Bao mice die around birthresulting from severe macrocytic anemia and show abnormal genitalglands of both genders.aging." @default.
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- W2351004097 date "2009-07-30" @default.
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- W2351004097 title "Gonadial Abnormality and Homozygous Decease from the Nonsense Mutationof Kit in W-3Bao Mouse" @default.
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