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- W2351005716 abstract "Objective To observe the expression and significance of p38MAPK in early embryos of mouse and explore the relationship between p38MAPK and the blastocyst implantation. Methods Mice early embryos were obtained at the following stages: two-cell, four-cell, eight-cell, morulae and blastocyst. The expression of p38MAPK in early embryos was examined by immunohistochemistry and immunofluorescence. The early mouse embryos were cultured in vitro and implanted into different culture medium in which different concentrations of SB220025(a inhibitor of p38MAPK, 0.2, 2, 20μmol) to observe the effect of p38MAPK inhibitor on early embryo development by trypan blue staining. Results The p38MAPKpositive staining was found in all the pre-implanted embryos and gradually increased as the development of embryos. SB220025 inhibited the development of embryos to the blastocyst stage, however, the embryos still developed continually and progressed to the blastocyst stage as the embryos were removed and placed in drug-free medium. Conclusion p38MAPK plays an important role in embryo development at pre-implantation interval, which could be inhibited by p38MAPK inhibitor." @default.
- W2351005716 created "2016-06-24" @default.
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- W2351005716 date "2014-01-01" @default.
- W2351005716 modified "2023-09-25" @default.
- W2351005716 title "Expression and significance of p38MAPK protein in mouse early embryos" @default.
- W2351005716 hasPublicationYear "2014" @default.
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