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- W2351027013 abstract "Objective:It is to investigate the effect of rhIL-13(recombinant human interleukine-13) on the differentiation of Dami cells,a megakaryocytic leukemia cell line, and the expression of IL-13Rα1(interleukine-13 receptor alpha 1)on Dami cells, and to elucidate the mechanism of IL-13-induced differentiation of Dami cells.Methods:After Dami cells were cultured in serum-free medium for 20 h, totle RNA was extracted from these cells treated with rhIL-13 for different time. The transcriptional levels of IL-13Rα1, GPⅡb and c-myc were analysed using RT-PCR. IL-13-induced expression of GPⅡb and c-myc was examined using flow cytometric analysis and immunohistochemistry, respectively. The results were analysed by image machine.Results:①Dami cells could express IL-13Rα1 mRNA. The expression of IL-13Rα1 mRNA was down-regulated in Dami cells treated with rhIL-13 for 4 h, and then the expression of IL-13Rα1 mRNA was resumed after 12 h of rhIL-13 treatment. ②rhIL-13 up-regulated the expression of GPⅡb, a megakaryocytic surface marker, on Dami cell at the levels of mRNA and protein. ③The expression of c-myc mRNA and protein levels was down-regulated in Dami cells treated with rhIL-13.Conclusion:IL-13 could promote the differentiation of Dami cells by down-regulating the expression of c-myc." @default.
- W2351027013 created "2016-06-24" @default.
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- W2351027013 date "2006-01-01" @default.
- W2351027013 modified "2023-09-24" @default.
- W2351027013 title "Interleukine-13 induces the differentiation of Dami cells and down-regulates the expression of transcription factor c-myc" @default.
- W2351027013 hasPublicationYear "2006" @default.
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