FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2351032941> ?p ?o ?g. }

• W2351032941 endingPage "91" @default.
• W2351032941 startingPage "83" @default.
• W2351032941 abstract "Epigenetics (particularly DNA methylation) together with environmental and genetic factors, are key to understanding the pathogenesis of many diseases including dementia. Disturbances in DNA methylation have already been implicated in dementia. Homocysteine metabolism, with folate and vitamin B12 as essential cofactors, is integral to methylation processes. We evaluated in a case-control study the association of global DNA methylation, homocysteine, folate and vitamin B12 status with dementia. Selected polymorphisms of genes previously associated with dementia development and the influence of various factors on DNA methylation were also investigated. 102 patients with dementia (53 with Alzheimer's disease, 17 with vascular dementia and 32 with mixed dementia) were recruited. The non-demented controls consisted of 45 age-matched subjects without dementia and 47 individuals with mild cognitive impairment. Global DNA methylation was determined by Imprint Methylated DNA Quantification Kit MDQ1 (Sigma-Aldrich, Gillingham, Dorset, UK). Plasma homocysteine, serum folate and vitamin B12 were determined by chemiluminescence. Plasma and erythrocyte 5-methyltetrahydrofolate and plasma methylmalonic acid (markers of folate and vitamin B12 status) were measured by HPLC. APOE, PON1 p.Q192R, MTHFR 677C > T (c.665C > T) and IL1B-511C > T polymorphisms were identified using PCR-RFLP methods. Patients with dementia had significantly higher concentrations of homocysteine (p = 0.012) and methylmalonic acid (p = 0.016) and lower folate (p = 0.002) and plasma 5-methyltetrahydrofolate (p = 0.005) than non-demented subjects. There was no difference in DNA methylation between patients and controls. A non-significant tendency to higher DNA methylation in patients with vascular dementia (p = 0.061) was observed. Multivariate regression analysis of all recruited individuals demonstrated a significant positive association between DNA methylation and folate (p = 0.013), creatinine (p = 0.003) concentrations and IL1B-511 T (p = 0.002) and PON1 192R (p = 0.049) alleles and negative association with fasting glucose (p = 0.004). The biochemical results showed significantly lower folate and vitamin B12 status in demented patients than controls. Global DNA methylation was associated with markers of folate status, creatinine, glucose and PON1 and IL1B polymorphisms." @default.
• W2351032941 created "2016-06-24" @default.
• W2351032941 creator A5004530335 @default.
• W2351032941 creator A5017445325 @default.
• W2351032941 creator A5020093791 @default.
• W2351032941 creator A5023223877 @default.
• W2351032941 creator A5035639680 @default.
• W2351032941 creator A5057636949 @default.
• W2351032941 creator A5059642395 @default.
• W2351032941 creator A5060148675 @default.
• W2351032941 creator A5063206287 @default.
• W2351032941 creator A5066854028 @default.
• W2351032941 creator A5078821678 @default.
• W2351032941 creator A5082286426 @default.
• W2351032941 date "2016-08-01" @default.
• W2351032941 modified "2023-10-14" @default.
• W2351032941 title "Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia" @default.
• W2351032941 cites W1776082370 @default.
• W2351032941 cites W1877630935 @default.
• W2351032941 cites W1931116526 @default.
• W2351032941 cites W1941610388 @default.
• W2351032941 cites W1948763420 @default.
• W2351032941 cites W1974119296 @default.
• W2351032941 cites W1974943956 @default.
• W2351032941 cites W1976464296 @default.
• W2351032941 cites W1981752009 @default.
• W2351032941 cites W1982354720 @default.
• W2351032941 cites W1983615455 @default.
• W2351032941 cites W1991235519 @default.
• W2351032941 cites W1991244004 @default.
• W2351032941 cites W1992393512 @default.
• W2351032941 cites W1995781460 @default.
• W2351032941 cites W1999659629 @default.
• W2351032941 cites W2001105374 @default.
• W2351032941 cites W2001988863 @default.
• W2351032941 cites W2008471043 @default.
• W2351032941 cites W2015635131 @default.
• W2351032941 cites W2016370157 @default.
• W2351032941 cites W2018529998 @default.
• W2351032941 cites W2019699796 @default.
• W2351032941 cites W2020388524 @default.
• W2351032941 cites W2021192988 @default.
• W2351032941 cites W2023155523 @default.
• W2351032941 cites W2026970282 @default.
• W2351032941 cites W2032212051 @default.
• W2351032941 cites W2034681842 @default.
• W2351032941 cites W2038003980 @default.
• W2351032941 cites W2038744774 @default.
• W2351032941 cites W2044530953 @default.
• W2351032941 cites W2050286601 @default.
• W2351032941 cites W2052316146 @default.
• W2351032941 cites W2052588755 @default.
• W2351032941 cites W2052792956 @default.
• W2351032941 cites W2053244527 @default.
• W2351032941 cites W2053901332 @default.
• W2351032941 cites W2057270928 @default.
• W2351032941 cites W2059483016 @default.
• W2351032941 cites W2062825859 @default.
• W2351032941 cites W2066430702 @default.
• W2351032941 cites W2071208072 @default.
• W2351032941 cites W2074750860 @default.
• W2351032941 cites W2076184646 @default.
• W2351032941 cites W2094212448 @default.
• W2351032941 cites W2094370427 @default.
• W2351032941 cites W2094425964 @default.
• W2351032941 cites W2097569022 @default.
• W2351032941 cites W2098656698 @default.
• W2351032941 cites W2099614709 @default.
• W2351032941 cites W2108167362 @default.
• W2351032941 cites W2110118235 @default.
• W2351032941 cites W2111774300 @default.
• W2351032941 cites W2112903461 @default.
• W2351032941 cites W2117873449 @default.
• W2351032941 cites W2122751858 @default.
• W2351032941 cites W2127632956 @default.
• W2351032941 cites W2132582013 @default.
• W2351032941 cites W2134010764 @default.
• W2351032941 cites W2143530310 @default.
• W2351032941 cites W2146824244 @default.
• W2351032941 cites W2148525284 @default.
• W2351032941 cites W2148988033 @default.
• W2351032941 cites W2151595202 @default.
• W2351032941 cites W2155656601 @default.
• W2351032941 cites W2156635660 @default.
• W2351032941 cites W2165715420 @default.
• W2351032941 cites W2209879584 @default.
• W2351032941 cites W2222383395 @default.
• W2351032941 cites W2254593627 @default.
• W2351032941 cites W2304507328 @default.
• W2351032941 cites W2331478100 @default.
• W2351032941 cites W579143072 @default.
• W2351032941 doi "https://doi.org/10.1016/j.exger.2016.05.002" @default.
• W2351032941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27167582" @default.
• W2351032941 hasPublicationYear "2016" @default.
• W2351032941 type Work @default.
• W2351032941 sameAs 2351032941 @default.
• W2351032941 citedByCount "33" @default.
• W2351032941 countsByYear W23510329412016 @default.

• next