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- W2351065510 abstract "Objectives:To evaluate the expression of EGFR and Ki67 as well as their clinical significance in phyllodes tumors(PT) of the breast.Methods:The expression of EGFR and Ki67 in stroma was observed in 33 mammary PT(benign,15;borderline,10;and malignant,8) using EnVision immunohisto-chemistry,to evaluate the correlation of the expression with the degree of malignancy.Results:The positive rate of EGFR expression was 33.3%(5 /15) in benign PT,80.0%(8/10) in borderline PT,and 100%(8/8)in malignant PT,respectively.The expression of EGFR showed a significant difference between benign and malignant lesions(P0.05).The positive rate of Ki 67 was 13.3%(2/15)in benign PT,80.0%(6/10)in borderline PT,and 100%(8/8)in malignant PT ,all of benign PT stained weakly positive,50.0% of malignant PT stained strongly positive.The difference was also significant(P0.05).The expression of EGFR and Ki67 were associated with the progression in grades of PT of the breast.The expressions in benign PT were lower than those in borderline and malignant PT.The staining intensity of EGFR was correlated positively with that of Ki67(r=0.6073,P0.001).Conclusion:EGFR and Ki67 may be used as indicators to detect the degree of PT malignancy.It is suggested that therapy targeting of EGFR might be promising in the adjunctive treatment of malignant PT." @default.
- W2351065510 created "2016-06-24" @default.
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- W2351065510 date "2007-01-01" @default.
- W2351065510 modified "2023-09-25" @default.
- W2351065510 title "Expression of EGFR and Ki67 in phyllodes tumors of the breast and its clinical significance." @default.
- W2351065510 hasPublicationYear "2007" @default.
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