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- W2351065543 abstract "Objective To establish a rat model with the combination of D-galactosamine (D-GalN) and common biliary duct ligation(CBDL), and identify the activation and proliferation of oval cells during liver regeneration following hepatic damage.Methods CBDL was performedin in Male Sprague-Dawley rats weighing about 180g each, and then D-GalN was administered intraperitoneally at the dose of 2.0g/kg body weight after the operation. Rats in control group not received any treatment. Three rats were killed every 24 hours after the treatment. A single injection of 5'-bromodeoxyuridine (BrdU) was given intraperitoneally at the dose of 50mg/kg body weight to the animals 1 hour before sacrifice.Blood were drawned for liver function analysis and liver samples were taken for HE staining, electron microscope, immunohistochemistry and RT-PCR evaluation. Three random fields from each slide were counted for the cells with the morphological criteria for oval cells and showing cytoplasmic staining of OV-6. Results Many hepatic oval cells(HOC) were detected in the liver of rats given D-GalN plus CBDL, no HOC were observed in controls. The HOC was characterized by brown staining in the cytoplasm for AFP, OV-6 and in the nucleoli for Anti-BrdU separately. RT-PCR showed expression of GGTmRNA was much higher than the controls.Conclusion Successful rat model for HOC proliferation could be established with D-GalN plus CBDL. HOC could be activated and proliferated following liver damage and it was involved in liver regeneration." @default.
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- W2351065543 date "2004-01-01" @default.
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- W2351065543 title "Activation and proliferation of oval cells following acute hepatic damage" @default.
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