Matches in SemOpenAlex for { <https://semopenalex.org/work/W2351080102> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2351080102 endingPage "6" @default.
- W2351080102 startingPage "1140" @default.
- W2351080102 abstract "Yinqiaojiedu honeyed pills were equally divided into 1/4, 1/8, 1/12, and 1/16 parts. The materiomics release rates within 12 h of the intact Yinqiaojiedu honeyed pills and the divided granules were determined by the paddle method with a rotate speed at 100 r x min(-1), and the materiome was quantified by UV-scan and Kalman filter methods. The intact Yinqiaojiedu honeyed pills behaved typical sustained release profiles, while the well-divided portions also maintained a sustained release profile over 2-4 h. The release rates were well correlated with the extents for the divisions of the pills. The Weibull distribution parameters, Td and T50, were reduced in line with the particle size, indicating that the ways of administration of the pills may play a role in the in vivo pharmacokinetics of the pills. The visualization results showed obvious difference of materiomic release synchronicities between the intact pills and the equally divided particles, and the divisions enhanced the asynchronization. Therefore the novel theory of materiomic release/dissolution kinetics of traditional Chinese medicines (TCMs) quantitatively proved the traditional dosage form, namely, honeyed pills, as a prototype of the sustained-release dosage form with a visualization of the scientific connotation to the old saying in the classics of TCM, Pills, the moderate ones in action. In terms of materiome increase for each period of the release profiles, the materiomic release synchronicity was visually demonstrated. The novel theories provided methodological basis for the evaluation of traditional dosage forms and the design of the modern drug delivery systems for TCMs." @default.
- W2351080102 created "2016-06-24" @default.
- W2351080102 creator A5023862876 @default.
- W2351080102 creator A5026614129 @default.
- W2351080102 creator A5043318906 @default.
- W2351080102 creator A5062452184 @default.
- W2351080102 creator A5074563464 @default.
- W2351080102 creator A5085071061 @default.
- W2351080102 date "2008-11-01" @default.
- W2351080102 modified "2023-09-27" @default.
- W2351080102 title "[Application of the theories of materiomic release kinetics to the evaluation of the sustained release kinetics and synchronicity of yinqiaojiedu honeyed pills]." @default.
- W2351080102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19239035" @default.
- W2351080102 hasPublicationYear "2008" @default.
- W2351080102 type Work @default.
- W2351080102 sameAs 2351080102 @default.
- W2351080102 citedByCount "2" @default.
- W2351080102 crossrefType "journal-article" @default.
- W2351080102 hasAuthorship W2351080102A5023862876 @default.
- W2351080102 hasAuthorship W2351080102A5026614129 @default.
- W2351080102 hasAuthorship W2351080102A5043318906 @default.
- W2351080102 hasAuthorship W2351080102A5062452184 @default.
- W2351080102 hasAuthorship W2351080102A5074563464 @default.
- W2351080102 hasAuthorship W2351080102A5085071061 @default.
- W2351080102 hasConcept C121332964 @default.
- W2351080102 hasConcept C148898269 @default.
- W2351080102 hasConcept C185592680 @default.
- W2351080102 hasConcept C33923547 @default.
- W2351080102 hasConcept C62520636 @default.
- W2351080102 hasConcept C71924100 @default.
- W2351080102 hasConcept C81603835 @default.
- W2351080102 hasConcept C98274493 @default.
- W2351080102 hasConceptScore W2351080102C121332964 @default.
- W2351080102 hasConceptScore W2351080102C148898269 @default.
- W2351080102 hasConceptScore W2351080102C185592680 @default.
- W2351080102 hasConceptScore W2351080102C33923547 @default.
- W2351080102 hasConceptScore W2351080102C62520636 @default.
- W2351080102 hasConceptScore W2351080102C71924100 @default.
- W2351080102 hasConceptScore W2351080102C81603835 @default.
- W2351080102 hasConceptScore W2351080102C98274493 @default.
- W2351080102 hasIssue "11" @default.
- W2351080102 hasLocation W23510801021 @default.
- W2351080102 hasOpenAccess W2351080102 @default.
- W2351080102 hasPrimaryLocation W23510801021 @default.
- W2351080102 hasRelatedWork W2188495484 @default.
- W2351080102 hasRelatedWork W226209456 @default.
- W2351080102 hasRelatedWork W2295562351 @default.
- W2351080102 hasRelatedWork W2323646599 @default.
- W2351080102 hasRelatedWork W2349864971 @default.
- W2351080102 hasRelatedWork W2351935170 @default.
- W2351080102 hasRelatedWork W2356428187 @default.
- W2351080102 hasRelatedWork W2358924987 @default.
- W2351080102 hasRelatedWork W2359622048 @default.
- W2351080102 hasRelatedWork W2361142815 @default.
- W2351080102 hasRelatedWork W2362435845 @default.
- W2351080102 hasRelatedWork W2367256290 @default.
- W2351080102 hasRelatedWork W2367717439 @default.
- W2351080102 hasRelatedWork W2373164896 @default.
- W2351080102 hasRelatedWork W2376979005 @default.
- W2351080102 hasRelatedWork W2382773574 @default.
- W2351080102 hasRelatedWork W2385846288 @default.
- W2351080102 hasRelatedWork W2783396437 @default.
- W2351080102 hasRelatedWork W2783518183 @default.
- W2351080102 hasRelatedWork W2784211233 @default.
- W2351080102 hasVolume "43" @default.
- W2351080102 isParatext "false" @default.
- W2351080102 isRetracted "false" @default.
- W2351080102 magId "2351080102" @default.
- W2351080102 workType "article" @default.