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- W2351097899 abstract "Objective To study the effects of betahistine on survival time in mice with hepatoma and turmor weight in mice with sarcoma.Methods Hepatoma H_ 22 and sarcoma S_ 180 were transplanted to mice and the effects of betahistine were observed.Results The mice bearing H_ 22 were treated with 6.67mg/kg,13.33mg/kg or 26.67mg/kg betahistine for 7 days,the life prolongation rate was 5.48%,8.22% and 16.44%,respectively,which was positively correlated with the dosage. The survival time of 26.67mg/kg betahistine group was significantly increased compared with the control group(P0.05).The mice bearing S_ 180 were treated with 6.67mg/kg,13.33mg/kg or 26.67mg/kg Betahistine for 7 days and the tumor weight was decreased ,the inhibition rate was 6.83%,9.13% and 18.05%,respectively,which was positively correlated with the dosage. The turmor weight of 26.67mg/kg betahistine group was significantly decreased compared with the control group(P0.05).Conclusion The results suggest that betahistine can prolong the survival time in mice with hepatoma H_(22) and inhibite tumor-growth in mice with sarcoma S_(180). ." @default.
- W2351097899 created "2016-06-24" @default.
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- W2351097899 date "2006-01-01" @default.
- W2351097899 modified "2023-09-23" @default.
- W2351097899 title "Effects of betahistine on survival time in mice with hepatoma and tumor weight in mice with sarcoma" @default.
- W2351097899 hasPublicationYear "2006" @default.
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