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- W2351100521 abstract "Objective To research the role of Jagged 1 in physiological and pathological neovascularization. Methods The expression of Jagged 1 were detected in endothelial cells by immunocytochemistry.The expression of Jagged 1 were detected in blood vessel of chick chorioallantoic membrane by immunofluorescence and Western blot.The expression of Jagged 1 were detected in normal colorectal mucosa tissue and three colorectal cancers with large,median and small volume by immunohistochemistry and Western blot. Results( 1)Results of immunocytochemistry showed that Jagged 1 is a cell transmembrane protein and express in the cell membrane.( 2)Successfully established the dynamic blood vessel developmental model of chick chorioallantoic membrane, The dynamic blood vessel developmental model of chick chorioallantoic membrane showed that the vascular network in chorioallantoic membrane develops gradually with embryo age and reveals the process of neovascularization, vigorous growth and wilt dynamically. Results of immunofluorescence and Western blot revealed that Jagged 1 has different expression profiling at different period of vascular development.The expression of Jagged 1 increased with the increasing of physiologic vessels,vessel density,blood supply.( 3)Results of immunohistochemistry performed on hemangioma and colorectal cancer,Jagged 1 was widely expressed in neonatal vessels originated from hemangioma proliferation and few expressed in normal skin tissue.The expression of Jagged 1 was related to the tumor size in colorectal cancer. Conclusion The expression of Jagged 1 up-regulated in endothelial cells,primary period of vascular development and tumor angiogenesis,which may be an early event in neovascularization involved in inducing the expression of downstream gene." @default.
- W2351100521 created "2016-06-24" @default.
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- W2351100521 date "2011-01-01" @default.
- W2351100521 modified "2023-09-25" @default.
- W2351100521 title "Study of the role of Jagged 1 in physiological and pathological neovascularization" @default.
- W2351100521 hasPublicationYear "2011" @default.
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