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- W2351102346 abstract "OBJECTIVE To study the clinical significance of monitoring the serum methotrexate concentration (MTX) after administration with high dose MTX. METHODS High dose methotrexate citrovorum factor (CF) rescue was administered to 40 patients with malignant tumor. The serum MTX concentrations in 24 h and 48 h was monitored by HPLC. The dose of Cf was adjusted according to the levels of MTX in serum. RESULTS The serum concentrations of MTX at 0h in all patients were more than 1×10 -5 mol·L -1 ,and were more than 1×10 -6 mol·L -1 at 24 h. If concentration more than 5×10 -6 mol·L -1 at 24 h or more than 1×10 -6 mol·L -1 at 48 h, toxic adverse reaction may be observed in some patients. After raising the CF dose, the adverese reaction disappear.CONCLUSIONS Under serum concentration monitoring,using high dose methotrexate citrovorum factor (CF) rescue to treat malignant tumor was efficacious and safe." @default.
- W2351102346 created "2016-06-24" @default.
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- W2351102346 date "2001-01-01" @default.
- W2351102346 modified "2023-09-28" @default.
- W2351102346 title "High dose methotrexate treatment for malignant tumor and the serum concentration monitoring" @default.
- W2351102346 hasPublicationYear "2001" @default.
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