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- W2351104589 abstract "Objective To detective whether rheumatoid arthritis(RA)could cause dysfunction of endothelium and accelerate progress of atherosclerosis(AS)through dysfunction as patients of RA patients are liable to AS.Methods Detection and comparison of vasodilatation rate of aorta to acetylcholine and sodium nitroprusside and expression level of iNOS and eNOS in vessel of collagen-induced arthritis(CIA)mice and the same age control mice.Results Vasodilatation rate of aorta to acetylcholine was 88.70±22.90% in control mice while that in CIA mice decreased to 53.90±18.40%(p0.01)No significant differences between two groups to sodium nitroprusside. Expression level of eNOS decreased while iNOS increased in vessel in CIA mice.Conclusion Endothelium dysfunction existed in CIA mice and positive correlation with severity of RA ." @default.
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- W2351104589 date "2011-01-01" @default.
- W2351104589 modified "2023-09-24" @default.
- W2351104589 title "Collagen-induced Arthritis Mice Existed Endothelial Dysfunction ---- The New Evidence of Rheumatoid Arthritis Accelerated Atherosclerosis" @default.
- W2351104589 hasPublicationYear "2011" @default.
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