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- W2351117149 abstract "Objective To study the effects of atorvastatin on the levels of plasma nitrogen monoxidum,fibrinogen and D-dimer.Methods One hundred and twenty patients with coronary heart disease were randomly divided into 2 groups,the atorvastation therapeutic group(n=60) and conventional therapeutic group(n=60).The other 40 healthy persons were recruited as control group.The levels of plasma nitrogen monoxidum were determined with colorimetry.The levels of plasma fibrinogen were determined with automated coagulometer method.The level of D-dimer was dertermined with colloidal gold method.Results The level of plasma nitrogen monoxidum was decreased significantly and the levels of fibrinogen,D-dimer were increased significantly in the patients of coronary heart disease compared to those in control group(P0.01,P0.01,P0.01).There was no significant difference in the levels of plasma nitrogen monoxidum,fibrinogen and D-dimer between the atorvastation therapeutic group and conventional therapeatic group(P0.05) before the treatment.After 8-week atorvastatin therapy,the level of plasma nitrogen monoxidum was increased significantly,the levels of plasma fibrinogen and D-dimer were decreased significantly(P(0.01)).There was no significant difference in the conventional therapeutic group(P0.05).Conclusion It is suggested that the therapy with atorvastatin could protect vascular endothelial function,improve the blood supply of cardiac muscle,and inbibit the process of coronary heart disease." @default.
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- W2351117149 date "2006-01-01" @default.
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- W2351117149 title "Effect of atorvastatin on the levels of plasma nitrogen monoxidum fibrinogen and D-dimer in coronary heart disease" @default.
- W2351117149 hasPublicationYear "2006" @default.
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