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- W2351145782 abstract "Objective A multiple center research involving 6 hospitals was carried out to evaluate the left ventricular(LV) endocardial border echo enhancement effect and safety of perfluoropropane-albumin microsphere injection. Methods Diluted perfluoropropane-albumin microsphere injection was given intravenously to permitted objects at a dose of 0.01 ml/kg. Observers A and observers B evaluated the contrast effect respectively by self-comparison between pre-injection and post-injection. Results All 303 patients of 6 hospitals need to be given the microsphere injection only once at a dose of 0.01 ml/kg. Observers A had a result that in 0.7 % patients the LV endocardial border enhancemen reached Grade Ⅱ and in 99.3 % patients reached grade Ⅲ, while obervers B had a result that in 0.3 % patients reached grade Ⅱ and in 99.7 % patients reached grade Ⅲ. Both results were effective and had no statistic difference( P 0.05 ). The intercenter difference of LV contrast grade was also not of significance( P 0.05 ). After once injection both observers considered the number of clearly recognized endocardial border segments increased significantly. The number evaluated by observers A increased from 2.68 ± 0.95 to 5.99 ± 0.10 while from 2.82 ± 1.03 to 5.99 ± 0.11 by observers B( P 0.01 ). The results between two observers had no significant difference( P 0.05 ). The average contrast enhancement rate of LV endocardial border was 99.7 %. Perfluoropropane-albumin microsphere injection had no significant effection on vital signs such as blood prssure, heart rate and respiration. Electrocardiogram didn′t change markedly and the variance of the laboratory findings like blood and urine routine examination, hepatic and renal function was in normal range. Only one case( 0.33 %) had slight side-effects who suffered from mild nausea and diarrhea, which suggested the clinical safety of this contrast agent. Conclusions Perfluoropropane-albumin microsphere injection could enhance the resolution of LV endocardial borders and make the judgement of regional myocardial movement easier. It has little side-effects and will be appropriate for clinical use." @default.
- W2351145782 created "2016-06-24" @default.
- W2351145782 creator A5018338798 @default.
- W2351145782 date "2006-01-01" @default.
- W2351145782 modified "2023-09-23" @default.
- W2351145782 title "Improved left ventricular endocardial border echo resolution by perfluoropropane-albumin microsphere injection: a multiple center stage III clinical study" @default.
- W2351145782 hasPublicationYear "2006" @default.
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