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- W2351148614 abstract "Objective:To study the effect of that the conbined insulin-sulfonylurea and monoinsulin treatment of secondary sulfonylurea failures in type Ⅱ diabetes mellitus. We investigated one of the mechanisms of insulin-sulfonylurea in vitro. Methods: 54 subjects were studied in our article: 28 patients with mono-insulin treatment, 26 patients with insulin-sulfonylurea treatment. Adipose tissue incubation was done with fantus IG'Smethod. We took the method of radioreceptor assay to determine the number of insulin receptors and insulin-binding. Results: (1) The fasting blood glucose and HbAlc were controlled well in the insulin-sulfonylurea group and mono-ins group in a 3-month therapy. (2) There is no statistical difference in TG、 CH、 HDL between insulin-sulfonylurea group and mono-ins group. (3) Mono-insulin treatment caused an increase in weight and blood insulin,and(4) sulfonylurea can improve the reduction of insulin receptors and raise adipocytes' sensitivity to insulin. Conclusion: (1) Both insulin-sulfonylurea and mono-ins are good methods to treat secondary sulfonylurea failures in type Ⅱ diabetes mellitus. (2) Insulin-sulfonylurea group has lesser increasing of weight and blood insulin level than insulin group, and (3) the sulfonylurea can increase insulin's effect." @default.
- W2351148614 created "2016-06-24" @default.
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- W2351148614 date "2001-01-01" @default.
- W2351148614 modified "2023-09-25" @default.
- W2351148614 title "Contrast of Secondary Sulfonylurea Failures in Type II Diabetes Mellitus Treated with Insulin-sulfonylurea and Mono-Insulin" @default.
- W2351148614 hasPublicationYear "2001" @default.
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