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- W2351161282 abstract "Objective To observe the effects of GSH on apoptosis rate of lymphocyte and plasma level of TNF-α,IL- 6 on acute lung injury induced by sepsis and to investigate the mechanism of GSH protecting the lungs against acute lung in- jury rats induced by sepsis.Methods The acute lung injury(Aid)rats were established by cecal ligation and puncture (CLP).112 male SD rats were randomized into four groups,(1)sham operated group(sham),(2)ALI group,(3)GSH treated group(GSH)and(4)levofloxacin treated group(LEV).Each group was subdivided into 4 groups,e.g.3 hours group(T3),6 hours group(T6),12 hours group(T12)and 24 hours group(T24).The changes of plasma TNF-α and IL-6 were determined at different time.Histological examination of the lungs was also performed.Results The apoptosis rate of lymphocyte in Aid group was higher than sham group and GSH treated group.In ALI group,the plasma level of TNF-α in 6 hours group increased more obvious than the GSH treated group(P0.01).The plasma level of IL-6 in ALI group rose after 3 hours of CLP In GSH treated group,the plasma level of IL-6 after three hours of CLP was lower than ALI group(P 0.05).The histological changes of lung injury in ALI group were significantly severer than GSH treated group.Conclu- sion The study showed that GSH could inhibite apoptosis of lymphocyte and expression of TNF-α and IL-6 ,and had pro- tective effects on the lungs against acute lung injury induced by sepsis." @default.
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- W2351161282 date "2008-01-01" @default.
- W2351161282 modified "2023-09-24" @default.
- W2351161282 title "The Effects of GSH on Apoptosis Rate of Lymphocyte and Plasma Level of TNF-α,IL-6 on Acute Lung Injury Rats Induced by Sepsis" @default.
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