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- W2351183806 abstract "[Objective] To investigate the inhibitory effects and mechanisms of Qiweibaitouweng decoction on ulcerative colitis in mice.[Method] 130 Clean BALB / C mice were randomized into five groups: model group,Chinese medicine treatment group,Western medicine treatment group,normal group and Ethanol control group.Except the mice in normal group and Ethanol control group,all mice were induced by oxazolone enema(dissolved in 100% ethanol).The western medicine treatment group was given Sulfasalazine(SASP) by stomach lavage,Chinese medicine treatment group was given Qiweibaitouweng decoction by stomach lavage,The remaining three groups was given normal saline by stomach lavage,for one week.A daily record of mice weight,stool and hemafecia condition,fecal occult blood detection by benzidine method,and evaluating the disease activity index(DAI) to animal status.One weeks later,all the mice were killed and colon tissue preparation.To observe the histopathological changes of the colon,and determine the expression and compare the changes of IL-5 mRNA and IL-13 mRNA of colon in mice.[Result] Qiweibaitouweng can significantly improve mice weight and activity state,repair colonic tissue pathological damage,and reduce the expression levels of IL-5and IL-13 effectively.[Conclusion] Qiweibaitouweng decoction exerts protective effect in experimental colitis,the effect seems to be related to relieving inflammatory reaction,repairing mucosal injury and healing ulcer." @default.
- W2351183806 created "2016-06-24" @default.
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- W2351183806 date "2012-01-01" @default.
- W2351183806 modified "2023-09-23" @default.
- W2351183806 title "Investigation of the Effect of Qiweibaitouweng Decoction on Colitis in Mice" @default.
- W2351183806 hasPublicationYear "2012" @default.
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