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- W2351198677 abstract "Objective:To observe the protective effects of antagonistic expression of sodium butyrate against high mobility group box1 protein(HMGB-1) on liver ischemia-reperfusion injury in rats.Methods:With a rat model of liver ischemia-reperfusion 40 healthy male Wistar rats were randomly divided into five groups:sham-operation,ischemia-reperfusion,ischemic preconditioning,No.1 treatment and No.2 treatment groups,and the animals were given medicine 6 hours before and after ischemia-reperfusion.The plasma ALT,AST and TNF-αlevels and HMGB-1 in the liver tissue were measured,and the histopathologic hepatic alterations were also observed.Results:HMGB-1 concentration was increased in ischemia-reperfusion group,the plusma ALT,AST,TNF-α and HMGB-1 concentrations in ischemic preconditioning group,No.1 treatment group and No.2 treatment group were decreased compared with those in ischemia-reperfusion group.In ischemic preconditioning group,the levels of HMGB-1 AST,ALT and TNF-α were significantly higher than those in No.1 treatment group and No.2 treatment group.Conclusion:With the sodium butyrate pretreatment,the liver tissue was protected efficiently from ischemia-reperfusion injury." @default.
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- W2351198677 date "2007-01-01" @default.
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- W2351198677 title "Protective effects of sodium butyrate on ischemia-reperfusion injury in rat liver: An experimental study" @default.
- W2351198677 hasPublicationYear "2007" @default.
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