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- W2351207965 abstract "Objective To observe the changes of mediators concentration in sputum from patients with asthma and their correlations to asthma clinical symptom in seretide treatment.Methods 24 asthmatics and 9 normal controls were enrolled in this study.In same time with measured the peak of expiratory flow(PEF) value,to collect induced sputum,for analyze mediators concentration.And after treatment 1,3,6 months took remeasurement again.Sulfidopeptide-leukotrienes(sLT) measurement was performed with EIA kit,and water-solubility chemokine was measured with ELISA kit.Results sLT concentration level significant elevated in asthmatic groups(P0.05),but no significant change was shown during steroid therapy.After 3 months,PEF value was improvement significantly(P0.01),interleukin(IL) 6,10 concentration levels significant elevated(all were P0.05),eosinophil cationic protein(ECP) concentration was fall(P0.05).After 6 months,the changes of these cytokines were more marked,and interferon(IFN) gamma and tumor necroses factor(TNF) alpha concentrations falled significantly(all were P0.05).Conclusion sLT and IL-10 do not show significant change to steroid therapy,unless 3 months treatment had been taken." @default.
- W2351207965 created "2016-06-24" @default.
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- W2351207965 date "2005-01-01" @default.
- W2351207965 modified "2023-09-25" @default.
- W2351207965 title "Change of Inflammation Mediators in Sputum from Asthma Patients Treated by Seretide" @default.
- W2351207965 hasPublicationYear "2005" @default.
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