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- W2351219526 abstract "Objective: To explore the curative effect of treating hand eczema by narrow-band ultraviolet B phototherapy(NB-UVB)combined with compound Glycyrrhizin injection and the influence on peripheral blood IFN-γand IL-4 level. Methods: 160 cases with hand eczema were selected, and were randomly divided into observation group and control group, 80 cases per group. Patients in control group were given urea cream coated on the surface of the lesion, and patients in observation group were given local NB-UVB lesions irradiation combined with compound glycyrrhizin injection, and they were all treated for 4 weeks. Clinical manifestations, EASI score,serum IFN- γ and IL-4 in two groups were observed before and after treatment, and adverse reaction were noted. Results: After treatment, the total effective rate in observation group and control group were 90.00% and 72.50% respectively(P0.05), and EASI scores were both decreased on varying degrees(P0.01or P0.05), yet observation group's EASI scores were lower than that of control group(P0.05). Observation group's serum IFN- γ decreased and IL-4 increased(P 0.05), and there were statistical difference on corresponding index comparing with control group(P0.05). There were no obvious adverse reactions in two groups. Conclusion: NB-UVB combined with compound Glycyrrhizin injection has high total efficiency of treating hand eczema, and improves the lesions symptom of hand eczema, regulates Th1/Th2 cytokine to balance, also has high security, thus it has some guiding significance to hand eczema's clinical treatment." @default.
- W2351219526 created "2016-06-24" @default.
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- W2351219526 date "2013-01-01" @default.
- W2351219526 modified "2023-09-23" @default.
- W2351219526 title "Curative Effect of Treating Hand Eczema by Narrow-band Ultraviolet B Phototherapy Combined with Compound Glycyrrhizin Injection and the Influence on Peripheral Blood IFN-γ and IL-4 Level" @default.
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