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- W2351268355 abstract "Objective To investigate the effect of troglitazone(TGZ) combined with 9-cis-RA on the cell cycle of gastric carcinoma cell line SGC7901. Methods Human gastric cancer cell line SGC7901 cultured in vitro was treated with TGZ and 9-cis-RA,and then the effect of the growth of SGC7901 cells was detected by MTT assay,the cell cycle of the tumor cells was analyzed by flow cytometry,and the expression of p21 and p27 was detected by immunocytochemistry assays,respectively. Results MTT showed that at the time point of 72 nd hour after the treatment of TGZ combined with 9-cis-RA,the growth of SGC7901 cells was inhibited at the concentration of 50 μmol/L of TGZ,20 μmol/L of 9-cis-RA and 25 μmol/L+10 μmol/L of TGZ combined with 9-cis-RA,respectively(P0.05).Determination with Jin Zhengjun method showed that TGZ and 9-cis-RA had synergistic effect on the inhibition of SGC7901 cells.Immunocytochemical method showed that in 50 μmol/L TGZ group,20 μmol/L 9-cis-RA group and 10 μmol/L 9-cis-RA+25 μmol/L TGZ group the positive expression percentage of p21 and p27 increased(P0.05),as compared to the negative control and low concentration groups.Flow cytometry showed that in 50 μmol/L TGZ group,20 μmol/L 9-cis-RA group and 10 μmol/L 9-cis-RA + 25 μmol/L TGZ group the cells in G0/G1 phase proliferated(P0.05).Conclusions TGZ and 9-cis-RA can inhibit cell proliferation by inducing cell cycle arrest in SGC7901 cells,and the induction of cell cycle arrest is involved in the up-regulation of the expression of p21 and p27." @default.
- W2351268355 created "2016-06-24" @default.
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- W2351268355 date "2009-01-01" @default.
- W2351268355 modified "2023-09-25" @default.
- W2351268355 title "Experimental study on the effect of troglitazone combined with 9-cis-RA on the cell cycle of gastric carcinoma cell line SGC7901" @default.
- W2351268355 hasPublicationYear "2009" @default.
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