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- W2351294017 abstract "Objective:To study the expression of ERβ,C-erbB-2 in breast cancer and to analyze the correlation between the expression of ERβ and C-erbB-2 and endocrine therapy effective and prognosis in breast cancer patients.Methods:ERβ,C-erbB-2 were detected by PV-9000 immunohistochemical technique in 86 cases of breast invasive ductal carcinoma.The data was analyzed combining with clinicolpathological character and prognosis using χ2 test and Kaplan-Meier method.Results:(1)The expression of ERβ was significantly correlated with lymph node metastasis,clinical stage(P0.05),and no significant correlation with age,tumor size,menopause or not and pathological grading(P0.05);The expression of C-erbB-2 was significantly correlated with tumor size and lymph node metastasis(P0.05),and no significant correlation with age,clinical stage,menopause or not and pathological grading(P0.05);(2)For ERβ negative group,the 5-year overall and disease free survival rate in endocrine therapy group were 87.29% and 84.06%,in non-endocrine therapy group they were 53.87% and 53.87% respectively,there were significantly different(P0.05).Conclusion:(1)ERβ and C-erbB-2 may play important roles in the carcinogenesis and development of breast invasive ductal carcinoma.(2)Endocrine therapy is effective in ERβ negative breast cancer patients.Detecting ERβ is significant in judging the effect of endocrine therapy for breast cancer patient." @default.
- W2351294017 created "2016-06-24" @default.
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- W2351294017 date "2008-01-01" @default.
- W2351294017 modified "2023-09-23" @default.
- W2351294017 title "Correlation between expression of ERβ and C-erbB-2 and endocrine therapy effective in breast cancer patients" @default.
- W2351294017 hasPublicationYear "2008" @default.
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