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- W2351330777 abstract "Aim:To study the change of tumour necrosis factor alpha (TNF α) in cerebrospinal fluid (CSF) and its clinical significance in patients with cerebral infarction (CI) and multi infarct dementia(MD).Methods:CSF levels of TNF α were measured with radioimmunoassay in the controls for 32 cases, 72 patients with CI and 55 patients with MID. Mini Mental State Examination (MMSE) was used to examine the intellectual level of patients, with DSM Ⅳ diagnosis standard and Hachinski Ischemia Score as references.Results:TNF α concentration of CSF in MID acute episode group and CI acute phase group were significantly higher than that in normal controls respectively ( P 0 01);TNF α concentration in MID stationary phase group and CI recovery phase group was higher than that in normal controls ( P 0 05); TNF α concentration of CSF in MID acute episode group was significantly higher than that in CI recovery phase group. No significant difference was found in TNF α concentration of CSF between MID stationary phase group and CI recovery phase group ( P 0 05). There was no significant correlation between TNF α concentration of CSF and MSSE scores (γ=-0 0257, P 0 05).Conclusion:Our data suggest that TNF α may be involved in pathophysiological process of CI. However, TNF α could not directly indicate the intellectual status of MID." @default.
- W2351330777 created "2016-06-24" @default.
- W2351330777 creator A5068132266 @default.
- W2351330777 date "2002-01-01" @default.
- W2351330777 modified "2023-09-25" @default.
- W2351330777 title "Measurement of Tumour Necrosis Factor Alpha in Cerebrospinal Fluid of Patients with Cerebral Infarction and Multi-infarct Dementia" @default.
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