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- W2351345319 abstract "Objective To study the inhibition of curcumin on human breast cancer MCF-7 cell proliferation and angiogenesis related gene mRNA expression,explore the possible molecular mechanism of tumor suppressor.Methods MCF-7 cell in vitro was cultured.Cells were divided into curcumin high-dose group,middle-dose group,low-dose group,blank control group,Solvent control group.The growth data were obtained by MTT test.The mRNA transcript expression of ANGPTL3、VEGF was detected in MCF-7 by RT-PCR after treating with curcumin.Results ①Curcumin had remarkably inhibitive effects on the growth of MCF-7 in vitro.②The mRNA expression level of ANGPTL3、VEGF mRNA was down-regulated.Conclusions ①Curcumin could inhibit the growth of human breast cancer MCF-7 cell in vitro.②curcumin can down-regulate the mRNA transcript expression of some Angiogenesis-related genes mRNA.③the inhibition effects of curcumin on proliferation of MCF-7 cell were closely correlated with with ANGPTL3,VEGF down regulation." @default.
- W2351345319 created "2016-06-24" @default.
- W2351345319 creator A5045808558 @default.
- W2351345319 date "2011-01-01" @default.
- W2351345319 modified "2023-09-26" @default.
- W2351345319 title "Effects of curcumin on proliferation and angiogenesis-related genes in human breast cancer MCF-7 cell" @default.
- W2351345319 hasPublicationYear "2011" @default.
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