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- W2351345788 abstract "AIM: To observe the effect of Yiru Granule on the female rat of hyperprolactinemia models. METHODS: Subcutaneous injection of maxolon was applied to establishing the mice model with hyperprolactinemia.Rats were at random divided into five groups,model control group,bromocriptine group,Yiru Granule of high dose,middle dose and low dose,and one normal group.The treatment lasted 30 days,serum levels of PRL,T,FSH, LH,P and E_2 were measured.Finally,the apoptosis regulatory protein bcl-2 and bax were assayed through immunohistochemical method and we used picture-analysing instrument to dispose the data. RESULTS: The middle and high dosage of Yiru Granule could not only inhibit the level of prolactin of the hyperprolactinimia rat models,but also increase the levels of estrogen and progesterone(P0.05) in comparison with the control group;the proliferation of the endometrium significantly increased as well as the histochemical expression of bcl-2. CONCLUSION: Yiru Granules can regulate the serum hormone levels in rats with hyperprolactinemia by decreasing PRL and increase LH,FSH and E_2 levels.The results indicate that the mechanisms of Yiru Granules maybe regulate the expressions of Bcl-2Bax on the endometriotic and ovary cell apoptotic path way." @default.
- W2351345788 created "2016-06-24" @default.
- W2351345788 creator A5041273801 @default.
- W2351345788 date "2008-01-01" @default.
- W2351345788 modified "2023-09-25" @default.
- W2351345788 title "Effect of Yiru Granule on apoptotic expressions (Bcl-2/Bax) in endometriotic and ovary cell of the hyperprolactinemia models rat" @default.
- W2351345788 hasPublicationYear "2008" @default.
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