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- W2351357755 abstract "Objective To study the mechanism of pancreatic acinar cell injury by cearulein and sodium taurocholate.Methods The pancreatic acinar cells were isolated by one-step method and their primary culture then conducted.After administration of the cearulein and sodium taurocholate,the cell viability,amylase release rate,LDH leakage rate and changes of eytosolic Ca~(21)were evaluated.Re- suits In the pancreatic acinar cells disposed by cearulein,the cell viability was high,amylase release rate and LD leakage rate increased,the ratio of amylase to LDH was 4:1,the cytosolic calcium had a pulsate increase and the direction was from the secretory region to basolateral region.In those cells disposed by sodium taurocholate,the cell viability was low.amylase release rate and LDH leakage rate increased,the ratio of amylase to EDH was 1:1 and cytosolic calcium had a constantly low-level in- crease.However,there was no calcium spread between the secretory region and basolateral region. Conclusions The mechanism of pancreatic acinar cell injury by cearulein is different from that of the injury by sodium taurocholate." @default.
- W2351357755 created "2016-06-24" @default.
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- W2351357755 date "2006-01-01" @default.
- W2351357755 modified "2023-10-07" @default.
- W2351357755 title "Mechanism of pancreatic acinar cell injury by cearulein and sodium taurocholate" @default.
- W2351357755 hasPublicationYear "2006" @default.
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